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Biological Organs Have their Own Circadian Clocks Mo HongYi It is known that everybody has a Circadian rhythm. Interestingly, scientists
have discovered that the organs in our bodies are just like numerous independent
lives with their own internal clocks.
Scientists believed that the circadian rhythm of a body was strictly
controlled by the master clock located in the brain, but they now have
discovered that this is not true. In an article published in the May issue of
Nature (Vol. 417, 78 - 83 (2002)), researchers from Harvard Medical School and
some other research institutes reported an interesting discovery. By studying
the tissues from the hearts and livers of mice, they discovered that the
physiological activities of a body were controlled by the local circadian clocks
of the organs in the body. The chiming of each organ clock triggers different
waves of gene activities, which can be adjusted over time to accommodate new
schedules and life activities. The different organ clocks appear to be
strikingly idiosyncratic in appearance. For example, the clock located in the
liver and the one in the heart use very different sets of genes to perform
functions that are basically the same. In the article, Weitz explained,
"Different tissues have to be cycling for different reasons. This allows
organs to reset their activities according to their own priorities, which makes
a lot of sense."
The discovery shows that the organs have their own relatively independent
metabolic activities. Ancient Chinese science actually regards these organs as
independent lives. For example, the Tao school maintains that our human body is
a universe with various kinds of lives in it. Traditional Chinese medicine also
treats each organ as an independent system and each different organ with
different attributes. They have their own independent life activities, while
interacting with each other. For example, in traditional Chinese medicine, there
is the theory of five elements: Kidney belongs to water, Liver belongs to wood,
Lung belongs to metal, Spleen belongs to earth, etc.. Different organs interact
with each other via the principle of mutual generation and mutual inhibition
among the five elements. Moreover, ancient Chinese science believes that
everything in the world has its own spirit; therefore one would pay attention to
the time and season for picking the tea leaves, etc. In addition, there are
strict requirements for the virtue of the persons who pick the herbs and teas.
In a prescription of Traditional Chinese medicine, different components play
different roles in the formula, such as the "emperor," the
"minister," the "assistant," and the "envoy." The
belief that all things have their own spirits is consistent with scientific
experiments.
Posting date: 9/1/2002
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